Canada Gazette, Part I, Volume 159, Number 43: GOVERNMENT NOTICES

October 25, 2025

(Erratum)

DEPARTMENT OF THE ENVIRONMENT

CANADIAN ENVIRONMENTAL PROTECTION ACT, 1999

Notice with respect to the availability of an equivalency agreement with Alberta (upstream oil and gas sector)

Notice is hereby given that the notice bearing the above-mentioned title published in the Canada Gazette, Part I, Vol. 159, No. 40 (PDF, 443KB), Saturday, October 4, 2025, on page 1929, should have been written as follows:

Pursuant to subsection 10(7) of the Canadian Environmental Protection Act, 1999, notice is hereby given that the Minister of the Environment makes available the Agreement on the Equivalency of Federal and Alberta Regulations Respecting the Release of Methane from the Oil and Gas Sector in Alberta, 2025.

The Agreement is available as of October 24, 2025, on the Canadian Environmental Protection Act Registry.

Contact

Clare Demerse
Director
Oil, Gas, and Alternative Energy Division
Department of the Environment
351 Saint-Joseph Boulevard
Gatineau, Quebec
K1A 0H3
Email: methane-methane@ec.gc.ca

Note: The HTML version has already been modified accordingly.

DEPARTMENT OF THE ENVIRONMENT

CANADIAN ENVIRONMENTAL PROTECTION ACT, 1999

Notice of intent to amend the Domestic Substances List under subsection 87(3) of the Canadian Environmental Protection Act, 1999 to indicate that subsection 81(3) of that Act applies to the substance hexanedioic acid, diisodecyl ester, also known as DIDA

Whereas the substance DIDA (Chemical Abstracts Service Registry Number [CAS RNfootnote 1] 27178-16-1) is specified on the Domestic Substances List;footnote 2

Whereas the Minister of the Environment and the Minister of Health (the ministers) have conducted an assessment of the substance under Part 5 of the Canadian Environmental Protection Act, 1999;footnote 3

And whereas the ministers suspect that the information concerning a significant new activity in relation to the substance may contribute to determining the circumstances in which the substance is toxic or capable of becoming toxic within the meaning of section 64 of the Canadian Environmental Protection Act, 1999,

Notice is hereby given that the Minister of the Environment intends to amend the Domestic Substances List, pursuant to subsection 87(3) of the Canadian Environmental Protection Act, 1999, to indicate that subsection 81(3) of that Act applies to any significant new activities relating to this substance, as set out in this notice.

Public comment period — October 25, 2025, to December 24, 2025

Any person may, within 60 days of publication of this notice, file with the Minister of the Environment comments with respect to this proposal. The assessment for the substance may be obtained from the Canada.ca (Chemical Substances) website.

How to participate: All comments must cite the Canada Gazette, Part I, and the date of publication of this notice and can be sent to the Director, Regulatory Operations, Policy, and Emerging Sciences Division, Department of the Environment, Gatineau, Quebec K1A 0H3,

In accordance with section 313 of the Canadian Environmental Protection Act, 1999, any person who provides information in response to this notice may submit with the information a request that it be treated as confidential.

Marc D’Iorio
Assistant Deputy Minister
Science and Technology Branch
On behalf of the Minister of the Environment

ANNEX

1. Part 1 of the Domestic Substances List is proposed to be amended by deleting the following:

2. Part 2 of the Domestic Substances List is proposed to be amended by adding the following in numerical order:

Column 1

Substance

Column 2

Significant new activity for which the substance is subject to subsection 81(3) of the Canadian Environmental Protection Act, 1999

27178-16-1 S′ 1. The use of the substance hexanedioic acid, diisodecyl ester in the manufacture of any of the following products:
  • (a) a consumer product to which the Canada Consumer Product Safety Act applies if it contains the substance at a concentration
    • (i) greater than 84% by weight, in the case of a non-aerosol lubricant or an automotive fluid,
    • (ii) greater than 15% by weight, in the case of an aerosol lubricant, or
    • (iii) equal to or greater than 0.2% by weight, in the case of any other product;
  • (b) a cosmetic as defined in section 2 of the Food and Drugs Act if it contains the substance at a concentration
    • (i) greater than 10% by weight, in the case of a lip liner, or
    • (ii) equal to or greater than 0.2% by weight, in the case of any other product;
  • (c) a natural health product as defined in subsection 1(1) of the Natural Health Products Regulations if it contains the substance at a concentration
    • (i) greater than 5% by weight, in the case of a rinse-off facial cleanser product, or
    • (ii) equal to or greater than 0.2% by weight, in the case of any other product; or
  • (d) a drug for human use to which the Food and Drug Regulations apply that is not a prescription drug if it contains the substance at a concentration equal to or greater than 0.2% by weight.
2. The importation of the substance hexanedioic acid, diisodecyl ester in any of the following products if the total quantity imported in all such products in a calendar year is greater than 10 kg:
  • (a) a consumer product to which the Canada Consumer Product Safety Act applies if it contains the substance at a concentration
    • (i) greater than 84% by weight, in the case of a non-aerosol lubricant or an automotive fluid,
    • (ii) greater than 15% by weight, in the case of an aerosol lubricant, or
    • (iii) equal to or greater than 0.2% by weight, in the case of any other product;
  • (b) a cosmetic as defined in section 2 of the Food and Drugs Act if it contains the substance at a concentration
    • (i) greater than 10% by weight, in the case of a lip liner, or
    • (ii) equal to or greater than 0.2% by weight, in the case of any other product;
  • (c) a natural health product as defined in subsection 1(1) of the Natural Health Products Regulations if it contains the substance at a concentration
    • (i) greater than 5% by weight, in the case of a rinse-off facial cleanser product, or
    • (ii) equal to or greater than 0.2% by weight, in the case of any other product; or
  • (d) a drug for human use to which the Food and Drug Regulations apply that is not a prescription drug if it contains the substance at a concentration equal to or greater than 0.2% by weight.
3. Despite sections 1 and 2, an activity is not a significant new activity if
  • (a) the substance is a research and development substance or a site-limited intermediate substance, as those terms are defined in subsection 1(1) of the New Substances Notification Regulations (Chemicals and Polymers); or
  • (b) the substance, or the product that contains the substance, is intended only for export.
4. For each proposed significant new activity, the following information must be provided to the Minister at least 90 days before the day on which the significant new activity begins:
  • (a) a description of the significant new activity in relation to the substance;
  • (b) the quantity of the substance that is anticipated to be used or imported annually;
  • (c) the information specified in items 3 to 6 and paragraphs 7(a) and (b) of Schedule 4 to the New Substances Notification Regulations (Chemicals and Polymers);
  • (d) the information specified in paragraphs 2(d) to (f) and 8(f) and (g) of Schedule 5 of the New Substances Notification Regulations (Chemicals and Polymers);
  • (e) a description of the product that contains the substance, the intended use and method of application of that product and the function of the substance in that product;
  • (f) the quantity of the product that contains the substance that is expected to be sold in Canada in a calendar year by the person proposing the significant new activity;
  • (g) all other information and test data in respect of the substance that are in the possession of the person proposing the significant new activity, or to which they may reasonably be expected to have access, and that permit the identification of adverse effects that the substance may have on the environment and human health and the degree of environmental and public exposure to the substance;
  • (h) the name of every government department or government agency, either outside or within Canada, to which the person proposing the significant new activity has provided information regarding the use of the substance and, if known, the department’s or agency’s file number, and, if any, the outcome of the department or agency’s assessment and the risk management actions in relation to the substance imposed by the department or agency;
  • (i) the name, civic and postal addresses, telephone number and, if any, the fax number and email address of the person proposing the significant new activity and, if they are not resident in Canada, of the person resident in Canada who is authorized to act on their behalf; and
  • (j) a certification that the information is accurate and complete, dated and signed by the person proposing the significant new activity if they are resident in Canada or, if not, by the person resident in Canada authorized to act on their behalf.
5. The information referred to in section 4 is to be assessed within 90 days after the day on which it is received by the Minister.

COMING INTO FORCE

3. This Order would come into force on the day on which it is registered.

EXPLANATORY NOTE

(This explanatory note is not part of the notice of intent.)

Description

The notice of intent (NOI) provides an opportunity for the public to comment on the proposed amendments to the Domestic Substances List footnote 2 (DSL) to apply the Significant New Activity (SNAc) provisions of the Canadian Environmental Protection Act, 1999 (CEPA) to the substance hexanedioic acid, diisodecyl ester (also known as DIDA), Chemical Abstracts Service Registry Number 27178-16-1, pursuant to subsection 87(3) of that Act.

Within 60 days of publication of the NOI, any person may submit comments to the Minister of the Environment (the Minister). These comments will be taken into consideration during the development of the Order amending the DSL to apply the SNAc provisions to this substance.

The DSL amendments are not in force until the Order is adopted by the Minister pursuant to subsection 87(3) of CEPA and registered. The Order must be published in the Canada Gazette, Part II.

In February 2019, an NOI to apply the SNAc provisions of CEPA to the substance DIDA was published in the Canada Gazette, Part I. During the public comment period, information was received that required revising the scope of the proposed SNAc requirements. Consequently, the NOI is being republished with revised SNAc requirements.

Applicability of the proposed Order

It is proposed that the Order amending the DSL requires any person (individual or corporation) engaging in a significant new activity in relation to the substance to submit a Significant New Activity Notification (SNAN) containing all of the information prescribed in the Order at least 90 days before the day on which the significant new activity begins.

In order to address human health concerns, the Order would target the use of the substance in the following products: consumer products to which the Canada Consumer Product Safety Act applies; cosmetics as defined in section 2 of the Food and Drugs Act; natural health products as defined in subsection 1(1) of the Natural Health Products Regulations; and drugs for human use to which the Food and Drug Regulations apply that can be obtained without a prescription. These products are potential sources of direct and significant human exposure to the substance.

For the manufacture of consumer products, notification would be required when the concentration of the substance is

For the importation of the substance in consumer products, notification would be required when the total quantity of the substance thus imported by any person (individual or corporation) in a calendar year is greater than 10 kg, and the product contains the substance at a concentration

For the manufacture of cosmetics, notification would be required when the concentration of the substance is

For the importation of the substance in cosmetics, notification would be required when the total quantity of the substance thus imported by any person (individual or corporation) in a calendar year is greater than 10 kg, and the concentration of the substance in the cosmetic is

For the manufacture of natural health products, notification would be required when the concentration of the substance is

For the importation of the substance in natural health products, notification would be required when the total quantity of the substance thus imported by any person (individual or corporation) in a calendar year is greater than 10 kg, and the product contains the substance at a concentration

For the manufacture of drugs for human use that are not prescription drugs, notification would be required when the concentration of the substance in the drug is equal to or greater than 0.2% by weight.

For the importation of the substance in drugs for human use that are not prescription drugs, notification would be required when the total quantity of the substance thus imported by any person (individual or corporation) in a calendar year is greater than 10 kg, and the concentration of the substance in the drug is equal to or greater than 0.2% by weight.

Activities not subject to the proposed Order

The use or importation of the substance as a research and development substance, a site-limited intermediate substance, or an export-only substance would not require the submission of a SNAN as these activities are not expected to result in exposure to the general population in Canada. The terms “research and development substance” and “site-limited intermediate substance” are defined in subsection 1(1) of the New Substances Notification Regulations (Chemicals and Polymers). An activity would not require the submissions of a SNAN if the substance, or the product that contains the substance, is intended only for export.

The proposed Order would not apply to uses of the substance that are regulated under the acts of Parliament listed in Schedule 2 of CEPA, including the Pest Control Products Act, the Fertilizers Act and the Feeds Act. The proposed Order would also not apply to transient reaction intermediates, impurities, contaminants, partially unreacted intermediates, or, in some circumstances, to items such as wastes, mixtures or manufactured items. However, it should be noted that individual components of a mixture may be subject to notification under the proposed Order. See subsection 81(6) and section 3 of CEPA, and section 3 of the Guidance document for the New Substances Notification Regulations (Chemical and Polymers) for additional information.

Information to be submitted

The NOI sets out the proposed requirements for information that would have to be provided to the Minister at least 90 days before the day on which the significant new activity begins. The Department of the Environment and the Department of Health will use the information submitted in the SNAN and other information to conduct environmental and human health assessments within 90 days after the complete information is received.

The information requirements in the proposed Order relate to general information in respect of the substance, details surrounding its use, and exposure information. Some of the proposed information requirements are set out in the New Substances Notification Regulations (Chemicals and Polymers).

Additional guidance on preparing a SNAN can be found in section 4 of the Guidance document for the New Substances Notification Regulations (Chemical and Polymers).

Compliance

When assessing whether or not a substance is subject to SNAc provisions,footnote 4 a person is expected to make use of information in their possession or to which they may reasonably be expected to have access. This means information in any of the notifier’s offices worldwide or other locations where the notifier can reasonably have access to the information. For example, manufacturers are expected to have access to their formulations, while importers or users of a substance, mixture, or product are expected to have access to import records, usage information and the relevant Safety Data Sheets (SDS).

Although an SDS is an important source of information on the composition of a purchased product, it should be noted that the goal of the SDS is to protect the health of workers in the workplace from specific hazards of chemical products. Therefore, an SDS may not list all product ingredients that may be subject to an order due to human health or environmental concerns. Any person requiring more detailed information on product composition is encouraged to contact their supplier.

Where a person involved in activities with the substance obtains information that reasonably supports the conclusion that the substance is toxic or is capable of becoming toxic, the person is obligated, under section 70 of CEPA, to provide that information to the Minister without delay.

Under section 87.1 of CEPA, any person who transfers the physical possession or control of a substance subject to an order shall notify all persons to whom the physical possession or control is transferred of the obligation to comply with the order, including the obligation to notify the Minister of any significant new activity and to provide all the required information outlined above.

In cases where a person receives physical possession and control of a substance from another person, they may not be required to submit a SNAN, under certain conditions, if the activities were covered by the SNAN submitted by the supplier on behalf of its clients.

A pre-notification consultation (PNC) is available for notifiers who wish to consult during the planning or preparation of their SNAN to discuss any questions or concerns they have about the prescribed information and test plans.

Where a person has questions concerning their obligations to comply with an order, believes they may be out of compliance, or would like to request a PNC, they are encouraged to contact the Substances Management Information Line.footnote 5

CEPA is enforced in accordance with the publicly available Compliance and Enforcement Policy for the Canadian Environmental Protection Act, 1999 (CEPA, 1999). In instances of non-compliance, consideration is given to the following factors when deciding which enforcement measure to take: nature of the alleged violation, effectiveness in achieving compliance with CEPA and its regulations, and consistency in enforcement.

DEPARTMENT OF THE ENVIRONMENT
DEPARTMENT OF HEALTH

CANADIAN ENVIRONMENTAL PROTECTION ACT, 1999

Publication after assessment of manganese and its compounds, including those specified on the Domestic Substances List and those identified for further consideration following prioritization of the Revised In Commerce List (section 77 of the Canadian Environmental Protection Act, 1999)

Whereas a summary of the draft assessment conducted on manganese and its compounds pursuant to paragraphs 68(b) and (c) of the Canadian Environmental Protection Act, 1999 is annexed hereby;

Whereas 3 of the 11 substances identified in Annex II below are substances identified for further consideration following prioritization of the Revised In Commerce List;

And whereas it is proposed to conclude that manganese and its compounds meet one or more of the criteria set out in section 64 of the Act,

Notice therefore is hereby given, for the purposes of paragraph 77(1)(a), that the Minister of the Environment and the Minister of Health (the ministers) propose to recommend to Her Excellency the Governor in Council that manganese and its compounds be added to Part 2 of Schedule 1 to the Act.

Notice is furthermore given that the ministers have released a risk management scope document for these substances to initiate discussions with stakeholders on the development of risk management options.

Public comment period — October 25, 2025, to December 24, 2025

Any person may, within 60 days after publication of this notice, file with the Minister of the Environment written comments on the measure the ministers propose to take and on the scientific considerations on the basis of which the measure is proposed. More information regarding the scientific considerations may be obtained from the Canada.ca (Chemical substances) website. The draft assessment and the risk management scope documents may also be consulted.

How to participate: All comments must cite the Canada Gazette, Part I, and the date of publication of this notice and be sent to the Substances Management Information Line, Department of the Environment, Gatineau, Quebec K1A 0H3, by one of the following methods:

In accordance with section 313 of the Canadian Environmental Protection Act, 1999, any person who provides information in response to this notice may submit with the information a request that it be treated as confidential. The request must provide reasons as provided for under subsection 313(2) of the Act.

Jacqueline Gonçalves
Director General
Science Reporting and Assessment Directorate
On behalf of the Minister of the Environment

Jacinthe David
Director General
Industrial Sectors and Chemicals Directorate
On behalf of the Minister of the Environment

Greg Carreau
Director General
Safe Environments Directorate
On behalf of the Minister of Health

ANNEX I

Summary of the draft assessment of manganese and its compounds

Pursuant to section 68 of the Canadian Environmental Protection Act, 1999 (CEPA), the Minister of the Environment and the Minister of Health have conducted a draft assessment of manganese and its compounds. This draft assessment focuses on the manganese moiety; therefore, it considers manganese in its elemental form, manganese substances, and manganese released in dissolved or particulate form. This draft assessment therefore considers all manganese-containing substances beyond those identified as priorities for assessment.

There are natural and anthropogenic sources of manganese to the environment. Natural sources of manganese include weathering of rock, ocean spray, forest fires, vegetation, and volcanic activity. Manganese is found in more than 100 minerals, including oxides, sulfides, carbonates, silicates, phosphates, and borates. Manganese is also present in coal and crude oil. The potential for cumulative effects was considered in this assessment by examining cumulative exposures to the manganese moiety. This draft assessment considers the combined exposure of humans and other living organisms to the manganese moiety from natural or anthropogenic sources, and whether it is present in environmental compartments (for example, water, sediment, soil, or air), food, or consumer products. All substances that have the potential to dissolve, dissociate, or degrade to release manganese through various transformation pathways can potentially contribute to the exposure of living organisms and the environment to bioavailable forms of manganese.

Anthropogenic sources of manganese include the incidental production of manganese (as a by-product) and the manufacture, import, and use of manganese and its compounds in products and manufactured items. Six substances in this draft assessment were included in a survey issued pursuant to section 71 of CEPA. According to information received in response to the survey, three manganese substances were reported to be manufactured in Canada in quantities ranging from one tonne to greater than 10 000 tonnes, and four substances were imported into Canada in quantities ranging from one tonne to 10 000 tonnes. In addition, information from the Canadian International Merchandise Trade Web Application indicates that an average of 14 000 tonnes of manganese-containing commodities were imported per year from 2017 to 2021.

Manganese is primarily used as an additive and a component in alloys for steel production. Other metallurgical uses of manganese include use in alloys with aluminium, copper, zinc, titanium, gold, silver, and bismuth for a variety of specific applications. Non-metallurgical uses of manganese include use in adhesives and sealants; animal feed; non-pesticidal agricultural products (for example, soil amendments, plant fertilizers); automotive, aircraft and transportation manufacturing and uses; batteries; building and construction materials; catalysts; cleaning and furnishing care (for example, cleaning products and odour control products); electronics; food additives; food packaging and other food uses; fuels and related products (for example, fuel additives); intermediates in the chemical industry; lubricants and greases; medical devices; metal materials; paints and coatings; pest control products; self-care products (for example, cosmetics, natural health products and non-prescription drugs); textiles; children’s toys; playground and sporting equipment; and water treatment.

Manganese is considered to be persistent in the environment, though it can transform into different chemical species and partition among different phases within an environmental compartment.

Manganese is an essential element that is actively assimilated and utilized by organisms. The bioavailability and toxicity of manganese are largely dependent on environmental characteristics (for example, pH and water hardness). Manganous Mn(II) and manganic Mn(IV) are the two primary oxidation states of manganese in the environment. The former is the more soluble and, therefore, more bioavailable form. It has been shown that lower trophic level organisms may actively assimilate manganese as an essential element for their biological functions, while organisms at higher trophic levels are able to at least partially maintain manganese homeostasis. Currently, there is no evidence to suggest that manganese may biomagnify via aquatic food chains.

At moderate to high concentrations, manganese causes mortality as well as effects on growth and reproduction in freshwater aquatic and in soil-dwelling organisms. Chronic predicted no-effect concentrations (PNECs) for manganese for freshwater organisms were derived using the long-term Canadian Water Quality Guidelines developed by the Canadian Council of Ministers of the Environment. Toxicity-modifying factors that influence the bioavailability and toxicity of manganese, including water hardness and pH, were incorporated to derive site-specific freshwater PNECs. The PNEC for soil-dwelling organisms was derived using a species sensitivity distribution approach.

A weight-of-evidence approach was used to determine the potential for ecological harm in Canada. Risk quotient analyses were performed for manganese by comparing predicted environmental concentrations (PECs) with freshwater and soil PNECs to determine the potential for ecological harm in Canada.

Facilities in three industrial sectors (pulp and paper, metal ore mining, and wastewater systems) as well as a group of steel-related sectors were examined. PECs derived from facilities in the pulp and paper, wastewater, and steel-related sectors resulted in few or no PNEC exceedances from the release of manganese in effluent. Furthermore, PECs that were derived from the application of biosolids from wastewater treatment resulted in no PNEC exceedances on agricultural lands in Canada. The analysis of effluent releases of manganese to water from metal ore mining facilities indicates that, while releases from most facilities are limited, there is a potential for harm to the aquatic environment as a result of manganese release from a small number of facilities across Canada.

Considering all available lines of evidence presented in this draft assessment, there is a risk of harm to the environment from manganese and its compounds. It is proposed to conclude that manganese and its compounds meet the criteria under paragraph 64(a) of CEPA, as they are entering or may enter the environment in a quantity or concentration or under conditions that have or may have an immediate or long-term harmful effect on the environment or its biological diversity. However, it is proposed to conclude that manganese and its compounds do not meet the criteria under paragraph 64(b) of CEPA, as they are not entering the environment in a quantity or concentration or under conditions that constitute or may constitute a danger to the environment on which life depends.

Manganese is an essential nutrient for human health, but elevated intake may result in adverse health effects. The central nervous system appears to be the most sensitive target of manganese toxicity in mammals. The developing fetus, infants, and children under three years of age are considered to be the most susceptible subpopulations for manganese toxicity, as excessive manganese exposure can adversely affect brain development. Time of exposure is crucial because susceptibility varies in different stages of brain development, and prenatal and early postnatal periods are considered the most sensitive developmental windows for manganese-induced neurotoxicity.

Subclinical neurological effects, including disturbances to fine motor control, memory, cognitive function, hyperactivity, and tremor are some of the earliest effects noted in humans and experimental animals following excess oral or inhalation exposure. Neurotoxic effects were used to characterize the risk for all routes of exposure. Neurobehavioural effects, which may have lasting impacts into later life, observed at low doses in neonatal rats, were used to characterize risk via the oral and dermal routes of exposure. Alterations in fine motor control (including hand dexterity) from an occupational study were used to assess the risk associated with inhalation.

Manganese is ubiquitous in air, drinking water, food, soil, and house dust and is present in thousands of products available to consumers. Food is the primary source of exposure for the general public, followed by drinking water. Formula-fed infants have the highest background exposure from environmental media, food (formula), and drinking water, when normalized by body weight. Concerns to human health were identified in association with drinking water, air, and products available to consumers.

To characterize risk from drinking water, manganese concentrations in drinking water from provinces and territories and some First Nation communities were compared to the maximum acceptable concentration (MAC) for drinking water (120 Âµg/L). Exceedances were observed in British Columbia, Saskatchewan, Manitoba, Quebec, New Brunswick, and Newfoundland and Labrador, as well as in some First Nations communities in Manitoba and in the Atlantic region.

To characterize risk from oral and dermal exposures from products available to consumers, exposure estimates were derived for the general population, including susceptible subpopulations, and compared to the lowest observed adverse effect level from neurodevelopmental studies in neonatal rats. Margins of exposure from the use of automotive products, household products, and textiles are considered adequate to address uncertainties in the health effects and exposure data used to characterize risk. Margins of exposure from the use of some children’s paint products, paint products, and self-care products (that is, cosmetics and natural health products) are considered potentially inadequate to address uncertainties in the health effects and exposure data used to characterize risk.

Hazard quotients (HQs) derived to characterize risk from inhalation exposure via outdoor air (ambient and with transit influence) and airborne manganese concentrations in the vicinity of the electric power generation, transmission, and distribution sector and the pulp, paper, and paperboard mills sector are considered adequate to address the uncertainties in the health effects and exposure data used to characterize risk. The HQs calculated for airborne manganese concentrations in the vicinity of the metal ore mining sector; the iron and steel mills and ferroalloy manufacturing sector; the agricultural, construction, and mining machinery manufacturing sector; the motor vehicle parts manufacturing sector; and the steel product manufacturing from purchased steel sector are considered potentially inadequate to address uncertainties in the health effects and exposure data used to characterize inhalation risk.

HQs calculated for air concentrations generated from the use of spray household products and some self-care products are considered adequate to address the uncertainties in the health effects and exposure data used to characterize inhalation risk. The HQs calculated for air concentrations generated from the use of aerosol spray paint (can), paint applied using an airless sprayer, and some loose face powders are considered potentially inadequate to address uncertainties in the health effects and exposure data used to characterize inhalation risk.

The human health assessment took into consideration those groups of individuals within the Canadian population who, due to greater susceptibility or greater exposure, may be more vulnerable to experiencing adverse health effects. Prenatal and postnatal life stages were identified as the life stages most susceptible to adverse health effects. The potential for elevated exposure among the Canadian population was examined in infants, young children, First Nations communities, and people living in the vicinity of industrial facilities. Young children and formula-fed infants were found to have higher exposure to manganese than adults. Compared to the general population, people living in the vicinity of industrial facilities have a potentially higher exposure to manganese in outdoor air.

Considering all of the information presented in this draft assessment, it is proposed to conclude that manganese and its compounds meet the criteria under paragraph 64(c) of CEPA, as they are entering or may enter the environment in a quantity or concentration or under conditions that constitute or may constitute a danger in Canada to human life or health.

ANNEX II

The assessment focuses on the manganese moiety and therefore considers manganese in its elemental form, manganese substances, and manganese released in dissolved or particulate form. Therefore, this draft assessment considers all manganese-containing substances beyond those identified as priorities for assessment.

Abbreviations: CAS RN, Chemical Abstracts Service Registry Number; DSL, Domestic Substance List; R-ICL, Revised In Commerce List

Table: List of manganese substances identified as priorities for assessment
CAS RN DSL or R-ICL name Common name List
1313-13-9 Manganese oxide Manganese dioxide DSL
1335-36-0 1,2,3-Propanetriol, mono(dihydrogen phosphate), manganese salt Manganese glycerophosphate R-ICL
1344-43-0 Manganese oxide Manganese oxide DSL
7439-96-5 Manganese Elemental manganese DSL
10101-66-3 table 2 note a Diphosphoric acid, ammonium manganese (3+) salt (1:1:1) Ammonium manganese pyrophosphate / Manganese violet DSL
12108-13-3 Manganese, tricarbonyl[(1,2,3,4,5-<C)-1-methyl-2,4-cyclopentadien-1-yl]- Methylcyclopentadienyl manganese tricarbonyl (MMT) DSL
18820-29-6 Manganese sulfide Manganese sulfide DSL
29193-02-0 L-Proline, 5-oxo-, manganese salt (1:?) Manganese pyroglutamate R-ICL
35355-77-2 table 2 note a C.I. Pigment Red 63:2 C.I. Pigment Red 63:2 DSL
68551-42-8 Fatty acids, C6-19-branched, manganese salts Manganous (C6-C19) branched alkanoate DSL
105883-50-9 Manganese, bis[N-(acetyl-.k.O)-L-methioninato-.k.O]- Manganese acetyl methionate R-ICL

Table 2 note(s)

Table 2 note a

This substance was included in this assessment as it was considered a priority on the basis of other human health concerns.

Return to table 2 note a referrer

Proposed overall conclusion

It is therefore proposed to conclude that manganese and its compounds meet one or more of the criteria set out in section 64 of CEPA.

It is also proposed to conclude that manganese and its compounds meet the persistence criteria but not the bioaccumulation criteria as set out in the Persistence and Bioaccumulation Regulations of CEPA.

The draft assessment and the risk management scope document for these substances are available on the Canada.ca (Chemical Substances) website.